However, there are groups of ERBB2+ breast cancer, lung cancer, esophageal cancers, and gastrointestinal cancers that are resistant to trastuzumab and tyrosine kinase inhibitors (Derakhshani et al, 2020; Bose and Ma, 2021; Hanker et al 2021; Zhang, 2021; Li et al, 2022). The gene discussed is ERBB2; the disease is lung carcinoma.