We found that (Figures 8B,C) the tumor volumes were significantly reduced in the mice bearing tumors that received the engineered constructs desARE3’UTR ERBB2-1, -3 and -30 compared to the wildtype and vector and that there were no significant differences between tumor volumes in the wildtype and the vector (Figures 8B,C). The gene discussed is ERBB2; the disease is neoplasm.