To validate our findings that the engineered destabilized 3’UTR of ERBB2 degrades ERBB2 in vivo and reduces ERBB2-driven tumor growth and volume in a mouse tumor-bearing model, we implanted 25 female NSG mice with 5 million NCI-H1975 cells on the flank and after 35 days, huge tumors engrafted (Figure 8A). This evidence concerns the gene ERBB2 and neoplasm.