To find the universal common kinases that mediate drug resistance both in osimertinib-resistant EGFR T790M lung cancer and trastuzumab-resistant breast cancer that are downregulated upon our destabilization of ERBB2, we triaged all the kinases downregulated in ERBB2 destabilized NCI-H1975 (Supplementary Table S2) found by RNA Seq with kinases downregulated in ERBB2 destabilized BT474 clone 5 (Figures 5A–C) found by the kinase array. This evidence concerns the gene EGFR and breast carcinoma.