Moreover, IQGAP1 is reported to regulate retinal neurite growth in chicken retina (Oblander and Brady-Kalnay, 2010) and to play a key role in the regulation of choroidal endothelial cells in the pathogenesis of Age-related Macular Degeneration (Ramshekar et al., 2021). Here, IQGAP1 is linked to age-related macular degeneration.