CLCN4 and Intellectual disability: In this study, a hemizygous variant c.2167C>T, predicted to change the amino acid p.Arg723Trp in the cytoplasmic domain of the ClC-4 protein (NP_001821.2) (Figure 2H) of uncertain significance, was identified in 2 diseased brothers of the affected family EP-09 with clinical presentations such as epilepsy, periods of seizures, memory loss, intellectual disability, dull memory, speech problems, and highly aggressive behavior.