Other signs of nonautoimmune hemolytic anemia are decreased hemoglobin, elevated reticulocytes, elevated LDH, hyperbilirubinemia with elevation of the indirect fraction, decreased haptoglobin and negative direct Coombs test results accompanied or not by a moderate increase in creatinine and hemoglobinuria [10], [11], [12]. The gene discussed is HP; the disease is Hyperbilirubinemia.