MTOR and leukemia: These findings have prompted researchers to target mTOR signaling using rapamycin or other inhibitors in GC-resistant leukemia.46,147 A recent work on a wide array of primary human T-ALL and PDX mice suggests that the combination of the mTOR inhibitor temsirolimus with dasatinib is even more efficacious in sensitizing GC-resistant T-ALL cells to dexamethasone.112