NR3C1 and acute lymphoblastic leukemia: These mutations are dispersed over the entire GR protein, but their impact on transcriptional activity and therapeutic outcome is variable.51,53 In addition to point mutations, also deletions of the long arm of chromosome 5, which encompass the NR3C1 gene, were observed in 4% (6/146)53 and 8% (17/200)54 of T-ALL patients at diagnosis.