Finally, we and others have shown that the JMJD3 demethylase is induced by NFκB and plays the role of NFκB and NOTCH1 partner in T-ALL via removing the H3 lysine 27 methyl marks, leading to gene derepression.158 In light of the competition between NOTCH1 and NFκB pathways with GR, use of JMJD3 inhibitors, such as GSKJ4, could be used to suppress oncogenic signaling pathways and induce sensitivity to GCs. The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.