Direct interaction between GR and LRH-1 regulates GC sensitivity in T-ALL, opening up possible perspectives to develop new therapeutic approaches for treating GC resistance.153 Estrogen-related receptor β (ESRRB) is another dexamethasone-inducible member of the ESRR family that binds to estrogen-related response elements. The gene discussed is NR3C1; the disease is acute lymphoblastic leukemia.