Recent studies exhibited that hypothalamic miRNAs including miR-548C-3p are potential contributors to different neurodegenerative diseases, also this author identified 29 novel hypothalamic MicroRNAs as a propitious therapeutic regimen for SARS-CoV-2 by regulating ACE2 and TMPRSS2 expression (75). The gene discussed is ACE2; the disease is neurodegenerative disease.