We found various cell signaling pathways are enriched including RAP1, MAPK, PI3K-AKT, RAS, and HIF-1 signaling pathways, etc. The signaling pathway of RAP1 was found to be a crucial regulator of cellular functions such as the formation and control of cell adhesion and junction and, also plays a major role during cell invasion and metastasis in different cancers (76). This evidence concerns the gene HIF1A and cancer.