IGF1 and hypertensive disorder: This functional maladaptation and increased microhemorrhage risk in hypertension may be related to the fact that IGF-1 deficiency disrupts the vascular remodeling process by impairing hypertension-induced adaptive media hypertrophy and dysregulating extracellular matrix remodeling, resulting in weakened cerebral arteries and increased circumferential stress (Tarantini et al., 2017; Norling et al., 2020).