IGF1 and Hypertension: IGF-1 deficiency also impairs the production and release of vasomediator eicosanoids from astrocytes, alters endothelial nitric oxide (NO) production, and increases susceptibility to hypertension-induced microhemorrhage (Toth et al., 2015a; Tarantini et al., 2017; Fulop et al., 2019).