APP and amyloidosis: Since c-Abl activity regulates the APP proteolytic processing (Yáñez et al., 2016), and its inhibition has been correlated with the decrease of amyloid burden in in vivo models of AD (Cancino et al., 2008; Estrada et al., 2016), a reduction of Aβ toxic species could underlie the reduction in memory impairments of AD mice.