APP and amyloidosis: We then performed the MWM, a task broadly used to evaluate spatial memory (Morris, 1984; Vorhees and Williams, 2006), in which amyloid pathology causes impaired performance in 12-month-old mice (Lalonde et al., 2005), and found that WT mice had significantly reduced escape latency across training days than APP/PS1 (5th day 12.21 ± 2.0 s vs. 34.77 ± 5.0 s, p* = 0.0104; 8th day 8.23 ± 2.6 s vs. 31.61 ± 5.9 s, respectively, p* = 0.0217) (Figure 2C).