Interestingly, β-Synuclein (SNCA), which is not a member of any canonical mitophagy genesets/pathways, is shown to interact with many mitochondrial outer membrane components and play a role in mitochondrial dysfunction (Malpartida et al., 2021) and mitophagy (Shaltouki et al., 2018) in Parkinson's disease. The gene discussed is SNCA; the disease is Parkinson disease.