Only very recently, a bioinformatic analysis reported GABARAPL1 as one of the genes differentially expressed in peripheral blood of AD patients (Wang et al., 2022), whereas proteome-wide analysis of brain extracellular vesicles seems to suggest that GABARAP proteins can be actively incorporated in these vesicles and this mechanism may be disrupted with AD progression (Gallart-Palau et al., 2020). Here, GABARAP is linked to Alzheimer disease.