ACTB and neurodegenerative disease: Changes in expression of the four genes (ACTB, VCP, ARF1 GABARAPL1) here identified by the bioinformatic analysis were further validated in two state-of-the-art models in the field of AD research, and in translational research aimed to target discovery and drug development for this neurodegenerative disease (de Leeuw and Tackenberg, 2019).