Single-nucleotide variants (SNVs) in PNPLA3 and TM6SF2 have been linked to NAFLD, cirrhosis, and HCC,25,26,27 whereas SNVs in HSD17B13 and MTARC1 reduce fat accumulation and protect against liver disease.28,29,30 In previous studies,31,32,33 SERPINA1 rs28929474 showed a significant association with liver disease severity. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.