For example, endothelial-derived Ser-214 containing tau oligomers may injure endothelial cells in the brain, which might lead to coagulopathies leading to hypoxic brain injury,45 which has been shown to lead to elevated phospho-tau in brains.46 It is also notable that the Ser-214 mutant tau that was generated following endothelial infection was able to seed neuronal tau, providing an alternative explanation for why the mutant may have reduced LTP. Here, MAPT is linked to blood coagulation disease.