MAPT and infection: Interestingly, the supernatant obtained from Ser-214-Ala mutant cells also inhibited LTP (Figure 6), indicating that synaptic plasticity is sensitive to oligomeric forms of the 1N4R tau isoform released from endothelial cells after ExoY+ infection, but insensitive to Ser-214 phosphorylation of tau (F(4,52) = 14.29, p ≤ .05, ANOVA; Tukey's post hoc test: control versus wild-type, p ≤ .05; control versus 1N4R: p ≤ .05; control versus Ser-214, p ≤ .05).