MAPT and infection: However, infection of PMVECs with the strains ExoY+ and PA103 led to robust activation of PKA (Figure 3B), with infection by either strain leading to increased Ser-214 phosphorylation of tau relative to that detected using PKA purified from uninfected control PMVECs (2.00 ± 0.79-fold increase for ExoY+-infected cells, p ≤ .05; 1.98 ± 0.37-fold increase for PA103-infected cells, p ≤ .05, N = 7).