APOB and coronary artery disorder: Our findings are also in line with the recent observation that genetic variants associated with a higher non-HDL-C/apoB ratio (linked in turn to SNPs affecting TG) are associated with increased CHD risk compared with variants associated with a lower non-HDL-C/apoB ratio.24 The apparent discordancy between the present and earlier8 results regarding the risk associated with apoB in TRL/remnants vs. LDL may be attributable, at least in part, to the choice of SNPs used as genetic instrumental variables and plasma lipid exposures (TG vs. TRL/remnant-C).