While, the expression of sarcosine oxidase (PIPOX), sarcosine dehydrogenase (SARDH), S-adenosylmethionine synthetase (MAT) and BHMT, which mediated the conversion between betaine and glycine, as well as its intermediate metabolites, sarcosine and S-adenosylmethionine showed decrease in R20523 family after infection. The gene discussed is MAT1A; the disease is infection.