CP and infection: As we previously observed, bacterial genes for the substrate binding proteins of Zn (adcA, adcAII, and lmb), Mn (mtsA), and a putative Ni (nikA) transport systems in GBS were all 10- to 20-fold upregulated during nDb and Db infection compared to GBS grown in culture (input) (2); however, these metal transport systems were less induced during Db infection when compared to nDb despite the increase in CP.