ARHGEF12 and viral infectious disease: On the one hand, L-arg can inactivate some viruses due to interactions with their lipid membranes.161,162 Moreover, L-arg produced by intestinal microbiota can enhance mucosal γδ T cell responses to viral infections.163 On the other hand, being a key metabolite for viral replication, L-arg depletion has been suggested as potent antiviral strategy against several viruses (summarized in93.