VAV1 and Alzheimer disease: This is in line with a study reporting that Ca2+‐dependent stimulation of NFAT is downmodulated by acetylated VAV1 and promoted by Lys deacetylation of VAV1 (Rodríguez‐Fdez et al., 2020), suggesting Lys acetylation of non‐histone proteins as a target effect of class I HDACis in modulating transcription of ER‐mitochondria cross‐talk in AD pathogenesis.