MAPT and Alzheimer disease: Alzheimer's disease (AD) is an age‐related neurodegenerative disease and the most common form of dementia, characterized by the deposition of insoluble aggregates of amyloid‐beta peptide (Aβ) and hyperphosphorylated tau, forming senile plaques and neurofibrillary tangles, respectively, particularly in the hippocampus (Knopman et al., 2021).