MFN2 and Alzheimer disease: In fact, disturbances in ER–mitochondria cross‐talk in AD have been mainly associated with an increased interaction between both organelles (Area‐Gomez et al., 2012), for example, through binding of mutant PS2 with Mfn2, which promotes mitochondrial Ca2+ overload, ΔΨm collapse, and apoptosis (Filadi et al., 2016).