However, we did not observe changes in mRNA levels of mitochondrial Ca2+ uniporter (Mcu) (Figure 3f), known to be largely responsible for mitochondrial Ca2+‐uptake in AD neurons (e.g., Ferreira et al., 2015), nor in the ER‐mitochondria tethering protein Pdzd8 (Figure 3g), which regulates cytoplasmic Ca2+ dynamics and consequently Ca2+ uptake by mitochondria (Hirabayashi et al., 2017), in response to AβO treatment. This evidence concerns the gene PDZD8 and Alzheimer disease.