To assess the effects of DHCR24 inhibition on hepatic steatosis, E3L.CETP mice were fed a HFCD while being treated with vehicle or the synthetic DCHR24 inhibitor SH42 (Muller et al, 2017; Korner et al, 2019) for a period of 8 weeks (Fig EV1A). The gene discussed is CETP; the disease is Hepatic steatosis.