Consistent with previous findings that LXRα‐deficient mice are more susceptible to high‐fat diet‐induced hepatic steatosis and inflammation (Endo‐Umeda et al, 2018; Endo‐Umeda & Makishima, 2019), we observed significant hepatic steatosis after 4 weeks of HFCD (Fig 4A and B). Here, NR1H3 is linked to fatty liver disease.