Since LXRα plays a crucial role in both lipid metabolism (Peet et al, 1998) and macrophage/KC homeostasis (Bischoff et al, 2010; Ishibashi et al, 2013; Endo‐Umeda et al, 2018), we next evaluated the effects of 4 weeks of SH42 treatment in HFCD‐fed LXRα‐deficient mice to evaluate the importance of LXRα in the observed protective effects of SH42 in ameliorating hepatic steatosis and inflammation. This evidence concerns the gene NR1H3 and fatty liver disease.