Since LXRα plays a crucial role in both lipid metabolism (Peet et al, 1998) and macrophage/KC homeostasis (Bischoff et al, 2010; Ishibashi et al, 2013; Endo‐Umeda et al, 2018), we next evaluated the effects of 4 weeks of SH42 treatment in HFCD‐fed LXRα‐deficient mice to evaluate the importance of LXRα in the observed protective effects of SH42 in ameliorating hepatic steatosis and inflammation. The gene discussed is CALCA; the disease is fatty liver disease.