NR1H3 and Hepatic steatosis: Since LXRα plays a crucial role in both lipid metabolism (Peet et al, 1998) and macrophage/KC homeostasis (Bischoff et al, 2010; Ishibashi et al, 2013; Endo‐Umeda et al, 2018), we next evaluated the effects of 4 weeks of SH42 treatment in HFCD‐fed LXRα‐deficient mice to evaluate the importance of LXRα in the observed protective effects of SH42 in ameliorating hepatic steatosis and inflammation.