Only mice that received AA developed significant airway eosinophilia versus AF and CA. AA induced eosinophilia in a dose‐dependent manner. BALF IL33 and lung IL5 & IL13 increased after AA challenge versus controlAlternaria specifically induced eosinophilia versus to other fungal allergens and induced FIZZ1, which persisted for daysFIZZ1 and acute inflammatory events induced by AA were STAT6‐dependent but not PAR2‐dependentFIZZ1 had roles in promoting eosinophilia, epithelial changes and peribronchial fibrosis. The gene discussed is IL5; the disease is atrial fibrillation.