AF exposure caused broncho‐interstitial infiltration of immune cells and GCM with higher mucus production and higher levels of eosinophilsIL6 deficiency correlated with decrease goblet cell numbers and mucin production, and decreased MUC5AC expressionIL6 deficiency drove increased eosinophil recruitment, lung pathology and collagen deposition in asthmatic miceIL6 deficient eosinophils dysregulated lung inflammation by upregulating TGF‐β and STAT3 phosphorylation, compromising barrier integrity. This evidence concerns the gene STAT3 and atrial fibrillation.