AA‐exposed mice treated with CDDO‐Me had reduced airway eosinophilia, IgE expression, peribronchial inflammation and GCM. IL5 and IL13 expression were also reduced. CDDO‐Me reduced or abolished IL33 release after AA exposureFull length IL33 remained in tissues, short IL33 was secretedIL33 release was associated with increased ROS, ATP release and Ca2+ signallingActivation of Nrf2 pathway reduced allergic pathology, type 2 cytokines and IL33 release. The gene discussed is IL33; the disease is Increased total eosinophil count.