Gas6−/− mice had suppressed AHR, decreased peribronchial and BALF inflammatory cells, reduced PAS staining and serum IgEExogenous Gas6 treatment to AF exposed mice led to increased peribronchial inflammation, increased BALF cells, increased serum IgE, and increased PAS stainingGas6 was elevated in asthmatic populations regardless of disease severityGas6 drove airway inflammation and was involved in airway remodelling. The gene discussed is IGHE; the disease is atrial fibrillation.