Reduced MCC and AF clearance in Scnn1b‐Tg mice and increased airway eosinophilia, IL4, IL5, IL13, ILC2 numbers and AHR. Scnn1b‐Tg mice spontaneously increased IL5, IL13, GCM and AHR versus WT vehicle control. Response to AF exposure was age‐dependentAirway inflammation, GCM, IL13 and eosinophilia were reduced in STAT6 KO Scnn1b‐tg mice and were further protected after AF exposureIL33 induced IL13 not dependent on STAT6 but blocked by IL33/ST2 pathway inhibitorsSTAT6 signalling mediated the inflammatory response to AFMucociliary dysfunction caused reduced clearance of AF. The gene discussed is IL1RL1; the disease is atrial fibrillation.