Bilateral CRSwNP; nasal congestion; impaired HRQoL; weight (30–150 kg); serum IgE (30–1500 IU/ml) AND ≥4 weeks of INCS before screening visit 1; total NPS ≥5; NCS ≥2; SNOT‐22 score ≥20. The gene discussed is IGHE; the disease is Nasal congestion.