POMC and Insulin resistance: Moreover, there is evidence showing that vasopressin can regulate secretion of adrenocorticotropic hormone (ACTH) leading to higher cortisol levels, which in turn contribute to hyperglycemia and insulin resistance.60, –62 Additional research to understand the physiologic and pathologic conditions in which vasopressin's effects take place will be necessary to understand what currently seem to be contradictory effects by the same hormone.