CREBBP and obesity due to melanocortin 4 receptor deficiency: P300/CBP activation by maternal obesity results in H3K27ac on the promoters of the Pparγ, p53 and p21Cip1 genes in mouse embryonic calvarial osteo-progenitors and in human umbilical cord MSCs, suggesting that obesity during pregnancy may impair osteogenesis in adult offspring [100].