Four secreted factors alkaline phosphatase, β‐lactamase, hemolytic phospholipase C, and CFTR inhibitory factor (Cif) of P. aeruginosa have been reported to be packaged in OMVs.[70] Cif is associated with reduced lung function in CF because Cif inhibits CFTR‐mediated chloride secretion in the airways thereby reducing mucociliary clearance[71] (Figure 2C). The gene discussed is CFTR; the disease is cystic fibrosis.