Dendritic cells (DCs) are central players in the immune response in bridging the innate and adaptive immune systems.[158, 159] Bacteria and bacteria‐derived BMVs have been shown to be internalized into DCs up‐regulating CD86 and MHCII molecules on DCs and producing TNF and IL‐12.[160] In B. fragilis OMVs have been shown able to stimulate DCs to produce pro‐inflammatory factors and cytokine.[161] The OMVs require IBD‐associated genes, ATG16L1, which is a CD (spell out CD here)‐risk gene specifically expressed in CD11c+ DCs, to protect against experimental colitis. This evidence concerns the gene ATG16L1 and colitis.