Under similar conditions, ATG16L1‐deficient mice failed to induce regulatory T cells (Tregs) and suppress mucosal inflammation and OMVs could not sufficiently mitigate the colitis.[161] In addition, M. tuberculosis MVs also substantially increase the expressions of MHC‐I, MHC‐II, and CD86 on DCs, further demonstrating that PAMPs in Mtb MVs induce DC maturation.[162]. The gene discussed is ATG16L1; the disease is colitis.