CD36 and neoplasm: showed that uptake of tumor cell‐derived miR‐375 was independent of exosomes but mediated by LDL.[18] Moreover, they identified CD36 as a receptor for mediating the uptake of LDL‐miR‐375 complex by tumor‐associated macrophage.[18] These extracellular miRNA pathways described above, however, still cannot explain the uptake of extracellular miRNAs that are neither encapsulated in EVs nor associated with RNA‐binding proteins or lipoproteins.