In addition, syndecans cooperate with integrins to promote F‐actin dynamics, mechanotransduction,[9, 10] and ECM assembly.[6, 11] The expression level of syndecans in cancer cells has been associated with tumor size, invasiveness, and metastatic capacity.[12] However, to date the investigation of the crosstalk between syndecan and integrin focuses mainly on long‐term (hours to days) adhesion, migration, and actin regulation. This evidence concerns the gene SDC1 and neoplasm.