DSG1 and acquired polycythemia vera: It is a matter of debate whether treatment cessation leads to the reproduction of anti-Dsg3 antibodies which were previously masked in the patients showing the transition to PF under treatment, resulting in a relapse where PV phenotype with mucosal involvement recurs, as seen in one of our patients.11, 13 Chang et al. reported a patient showing autoantibodies against both Dsg3 and Dsg1 after transitioning from PV to PF, which was supported clinically and histologically.