Targeted sequencing data in 20 patients with testicular DLBCL showed that the mutation frequencies of ≥20% were PIM1(12 cases, 60%), MYD88(11 cases, 55%), CD79B(9 cases, 45%), CREBBP(5 cases, 25%), KMT2D(5 cases, 25%), ATM(4 cases, 20%), and BTG2(4 cases, 20%). This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.