67例Ph染色体阴性MPN-AP/BP患者中,男31例(46.3%),女36例(53.7%),中位年龄为60(33~75)岁;MPN-AP 26例(38.8%),MPN-BP 41例(61.2%)。进展为MPN-AP/BP时血常规(中位数):HGB 82(36~208)g/L,WBC 14.58(0.58~182.51)×109/L,PLT 81(2~892)×109/L;乳酸脱氢酶(LDH)782.7(204.1~3150.1)U/L,中位外周血原始细胞比例15%(0~89%),中位骨髓原始细胞比例22.0%(2.5%~85.0%),输血依赖23例(34.3%)。5例患者既往已行脾切除术,其余62例患者中46例(74.2%)肋缘下可触及肿大脾脏。67例患者中60例有可供分析的染色体核型结果,其中染色体核型异常36例(60.0%);36例染色体核型异常患者中13例(36.1%)为复杂染色体核型,最常见的5种染色体核型异常为:+8(19.4%,7例)、+1(16.7%,6例)、der(1:7)(11.1%,4例)、−7(8.3%,3例)、−17(8.3%,3例)。. Here, CYGB is linked to myeloproliferative neoplasm.