综上所述,与中、老年MPN患者相比,年轻MPN患者症状负荷较轻、血栓事件发生率低、JAK2突变检出率较低、CALR突变检出率较高、非驱动基因突变及HMR突变的检出率均较低。. This evidence concerns the gene JAK2 and myeloproliferative disorder.