Apart from core snRNP components, the splicing-associated proteins LUC7L, LUC7L3, and DDX46, each with BAD repeats (a subtype of LCRs) homologous to those of U1-70K, are also enriched among AD-insoluble proteins, suggesting that these BAD-containing proteins shift toward insolubility during AD pathogenesis (23). This evidence concerns the gene SNRNP70 and Alzheimer disease.