PCSK9 and atherosclerosis: The resulting effect is that the APOE∗3-Leiden.CETP mouse displays a human-like lipoprotein profile when fed a cholesterol-containing diet, and in contrast to other available mouse models for atherosclerosis responds well to lipid-lowering medication such as statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.11