However, modern society behaviour does often not align with physiological circadian rhythms, resulting in CD, which has been associated with increased risk for cardiometabolic diseases in humans.3, 4, 5, 6, 7, 8 We previously demonstrated that CD is causally linked to accelerated atherosclerosis development in APOE∗3-Leiden.CETP mice.9 This evidence concerns the gene CETP and atherosclerosis.