To confirm that Nudt21 is tumor suppressive and mediates the pro‐metastatic activity of miR‐847a‐5p and the antimetastatic activity of Sec23a, OL‐shSec23a‐Nudt21‐OE, and OL‐miRNA‐487a‐Nudt21‐OE cell lines were constructed by lentivirus transfection (Fig. 6A–C) for conducting the rescue experiments both in vitro and in vivo. This evidence concerns the gene SEC23A and neoplasm.