TGFB2 and open-angle glaucoma: The KRAB repressors are functional proteins involved in the histone deacetylation.[122, 123] The unexplained hyperacetylation status of transforming growth factor beta‐2 (TGF‐β2) is one of the important cause of primary open‐angle glaucoma (POAG).[124] Rayana et al.