Persistent and latent infections associated with chronic infectious diseases pose significant challenges to achieving complete cure.[109] In patients with acquired immune deficiency syndrome (AIDS), the virus prefers to infect and integrate self‐gene fragments into host cells with specific receptors.[110] Hence, several researchers have knocked out the aforementioned receptor genes in induced pluripotent stem cells,[42] TZM‐Bl,[43] hematopoietic stem cells (HSPCs),[43] and primary CD4(+) T cells to reduce the infection rate of HIV (Figure 4D). This evidence concerns the gene CD4 and AIDS.