As shown in Fig. 5a, compared to vehicle-treated tumors, M8 treatment induced a significant increase in the number of tumor-infiltrating CD45+ leukocytes (44% vs 70%), including CD11b+Ly6C+ monocytes (19% vs 43%), and NK1.1+CD3− cells (2.4% vs 5.1%), whereas the proportion of CD4+CD3+ T cells was significantly decreased (71% vs 60%), and that of CD11b+F4/80+ macrophages slightly changed (59% vs 64%). The gene discussed is CD4; the disease is neoplasm.