Previous studies reported that essential MCU regulator (EMRE), a component of the calcium uniporter complex that includes the mitochondrial calcium uniporter (MCU), was assisted by MAIP1 to localize to the mitochondrial membrane62 and that hepatocyte-specific defects of MCU induced steatosis in mice, which was implicated in inactivation of Ampk, a master regulator of energy expenditure, in a cytoplasmic Ca2+-dependent manner63. This evidence concerns the gene MAIP1 and steatosis.