However, the inhibition of FKBP51 in the brain displays not a disadvantage but rather seems to be beneficial as previous studies have shown that the inhibition of FKBP51 in the brain helps to prevent psychological disorders as well as stress-related and endocrinologic-mediated diseases such as depression, type two diabetes and obesity [71]. Here, FKBP5 is linked to obesity due to melanocortin 4 receptor deficiency.