Moins-Teisserenc et al.49 conducted longitudinal analysis of severely ill adult burn patients over a period of 28 days post-admission (vs. healthy donors) and identified increased frequencies of Human Leukocyte Antigen – DR isotype positive monocytes associated with bacterial infection and septic shock, upregulation of adaptive T cells (CD4+ and CD8+) and a decline in the frequencies of unconventional lymphocytes such as γδ T cells and invariant natural killer T cells in critically burn patients at the time of admission. This evidence concerns the gene CD4 and bacterial infectious disease.