F2 and blood coagulation disease: The comparison also showed that ACLF patients had significantly higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil), and direct bilirubin (Dbil) (all P < 0.001) and more serious coagulopathy (with a significantly lower level of prothrombin activity (PTA) and a significantly higher international normalized ratio (INR), both P < 0.001) than those without ACLF.