Research on hyperandrogenemia and insulin resistance-related miscarriage in women showed that the important factors contributing to embryonic damage in polycystic ovary syndrome (PCOS)-like conditions include excessive production of ROS, mitochondrial dysfunction, and the inhibition of superoxide dismutase 1 (SOD1) and Keap1/Nrf2 antioxidant responses in the placenta [103]. This evidence concerns the gene SOD1 and Insulin resistance.