We identified the potential mechanisms and the hub genes in DCM pathogenesis, namely Phospholamban (Pln), Fatty acid binding proteins 3 (Fabp3), Tripartite Motif-containing Protein 63 (Trim63), Popeye domain containing 2 (Popdc2), and Troponin C1 (Tnnc1). Here, FABP3 is linked to familial dilated cardiomyopathy.