To further validate that tRF-22 regulates choroidal vasculopathy via the METTL3/Axin1/Arid1b axis in vivo, we conducted rescue experiments by co-infecting tRF-22 agomir and Axin1/Arid1b shRNA in FD model and laser-induced CNV model. This evidence concerns the gene ARID1B and Fabry disease.