HMGCR and cardiovascular disorder: Given there is a lack of association analysis of HMGCR and NPC1L1 gene polymorphisms with RCR (LDL-C > 1.8 mmol/L), the present study aimed to examine the association of HMGCR and NPC1L1 gene polymorphisms with RCR (LDL-C > 1.8 mmol/L) in patients with PTVD and found that variant HMGCR gene can cause an increased risk of RCR, which provides knowledge of new genetic factors that predispose to cardiovascular diseases.