Given there is a lack of association analysis of HMGCR and NPC1L1 gene polymorphisms with RCR (LDL-C > 1.8 mmol/L), the present study aimed to examine the association of HMGCR and NPC1L1 gene polymorphisms with RCR (LDL-C > 1.8 mmol/L) in patients with PTVD and found that variant HMGCR gene can cause an increased risk of RCR, which provides knowledge of new genetic factors that predispose to cardiovascular diseases. Here, NPC1L1 is linked to cardiovascular disorder.