NK-92 cells that were transduced with a vector encoding the anti-DLL3 scFv domain, an NKG2D transmembrane domain, and a 2B4-CD3 domain exhibited specific antitumor activity against DLL3-positive cell lines and induced tumor regression in a pulmonary metastasis tumor model in immunodeficient mice [76]. The gene discussed is KLRK1; the disease is neoplasm.