AKT1 and cancer: Since PI3K/AKT signaling causes nuclear translocation and transcriptional activity of NF-κB through downstream activation of the inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex, resulting in the inhibition of apoptosis and promotion of tumor growth in cancer models [26–28], we next assessed the effects of FFA1 agonism on activation of the p65 subunit of NF-κB as a measure of its activity.