The results of multivariate logistic regression (adjusted for age, sex, smoking history, drinking history, hypertension, and diabetes) indicated that ALDH2 A/A genotype in the co-dominant model (ALDH2 A/A vs. ALDH2 G/G) (adjusted OR 1.996, 95% CI 1.258–3.166, P = 0.003) and ALDH2 A/A genotype in the recessive model (ALDH2 A/A vs. ALDH2 G/G + G/A) (adjusted OR 1.802, 95% CI 1.168–2.781, P = 0.008) were significant risk factors for the presence of arteriosclerosis in multiple arteries. The gene discussed is ALDH2; the disease is arteriosclerosis.