The results of univariate logistic regression showed that ALDH2 rs671 A/A genotype (A/A vs. G/G: odds ratio (OR) 1.752, 95% confidence interval (CI): 1.115–2.751, P = 0.015) may increase risk of arteriosclerosis in multiple arteries, and MTHFR rs1801133 T/T genotype (T/T vs. C/C: OR 1.775, 95% CI: 1.084–2.907, P = 0.023) may increase risk of arteriosclerosis in multiple arteries. The gene discussed is ALDH2; the disease is arteriosclerosis disorder.