In agreement, lower proinflammatory cytokines (IL-1β and IL-6) and RANKL/OPG ratio were observed in peri-implant mucositis individuals in comparison to peri-implantitis individuals; this could be due to the lower peri-implant mucositis severity compared to peri-implantitis [75]. This evidence concerns the gene IL6 and Peri-Implantitis.