IDH1 and central nervous system cancer: K–M survival curves showed that in the three cohorts, the OS of patients with pan-gliomas (Figure 4D and Supplementary Figure 1A, 1B), LGG (Supplementary Figure 2A, 2E, 2I), GBM (Supplementary Figure 2B, 2F, 2J), IDH mutation (Supplementary Figures 3A, 4A, 4G) and IDH wildtype (Supplementary Figures 3B, 4B, 4H) in the low-risk group tended to be longer than that of patients in the high-risk group.