Unlike normal cells, cancer cells are rich in self DNA and cytoplasmic dsDNA, a byproduct of genomic instability, which activate the cGAS/STING pathway to promote or inhibit tumor development (Woo et al. 2014; Dou et al. 2017; Harding et al. 2017; Mackenzie et al. 2017). Here, CGAS is linked to neoplasm.