Cyclic diguanylate monophosphate (c-di-GMP), which activates STING, enhances the immunogenic and antitumor effects of a peptide vaccine against mouse B16 melanoma (TriVax boost immunization using the hgp100 peptide epitope (KVPRNDQWL))(Wang and Celis 2015). The gene discussed is STING1; the disease is melanoma.