This mechanism leads to the production of proinflammatory cytokines, including interferon (IFN), through the specific activation of the STING pathway in the TME, which promotes the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs) and induces a cytotoxic T lymphocyte (CTL)-mediated immune response. The gene discussed is STING1; the disease is neoplasm.