Given the importance of the cGAS/STING signal as the host’s defense mechanism against viral infections, colorectal carcinomas exhibiting defective cGAS/STING signaling may be more susceptible to various infections in addition to the oncolytic activity of DNA viruses such as herpes simplex virus (HSV) (Xia et al. 2016a). The gene discussed is CGAS; the disease is colorectal carcinoma.