Based on this, a protein-based cGAS-STING nanoagonist (bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions and β-lapachone) was discovered to enhance tumor-specific T-cell-mediated immune responses against poorly immunogenic solid tumors in vivo (Wang et al. 2022). This evidence concerns the gene STING1 and neoplasm.