STING1 and pulmonary fibrosis: In contrast, Savigny et al. reported that self-DNA levels were elevated and that cGAS and STING expression was increased in lung tissues in a bleomycin-induced fibrosis mouse model, and STING deficiency aggravated the progression of lung fibrosis with higher collagen deposition and excessive expression of remodeling factors (Savigny et al. 2020).