In contrast, Savigny et al. reported that self-DNA levels were elevated and that cGAS and STING expression was increased in lung tissues in a bleomycin-induced fibrosis mouse model, and STING deficiency aggravated the progression of lung fibrosis with higher collagen deposition and excessive expression of remodeling factors (Savigny et al. 2020). This evidence concerns the gene STING1 and fibrosis.