The STING S365A mutant, on the other hand, retains the ability to recruit TBK1 and activate NF-κB, and DNase II-/-STING-S365A mice developed severe polyarthritis, which was alleviated by neutralizing antibodies against TNF-α or the IL-6 receptor (Li et al. 2022b). This evidence concerns the gene STING1 and polyarticular arthritis.