IGHE and allergic asthma: Furthermore, total and HDM-specific serum IgE levels and IgE-positive B-cell fractions in bronchoalveolar lavage fluid and mediastinal lymph nodes were lower in STING knockout mice than in wild-type mice in an HDM-induced allergic asthma model, whereas a STING ligand, cyclic GMP-AMP, increased total and HDM-specific serum IgE levels and B-cell proportions in BALF (Gijon Mancheno et al. 2021).