MTHFR and neoplasm: Because of related with oncogenic dedifferentiation across tumor types according to previous study [38], machine learning identifies mDNAsi (Fig. 4A) and mRNAsi (Fig. 4B) stemness indices of MTHFR that are Scales ranged from 0 (low) to 1 (high) are analyzed to show the initiation and evolution of cancer.