MTHFR and acute lymphoblastic leukemia: MTHFR gene shows significantly lower expression in 17 tumors, including BRCA, CESC, LUAD, et al. However, the expression level of MTHFR gene has higher expression in 7 tumor samples (Fig. 1A) and exhibited widely expression in normal tissues, such as ALL, GBML, LAML, et al. Specifically, MTHFR shows highest expression in the LAML, lowest expression in the LIHC (Fig. 1A).