In Fig. 2A, high expressed MTHFR is linked to better prognosis of OS in LGG, LAML, ACC, but associated with the poorer OS prognosis in 7 cancer types, including KIPAN, HNSC, PAAD, et al. According to DSS analysis data (Fig. 2B), high MTHFR expression is predictor of favorable DSS among patients with LGG, UCEC, LUSC, et al., but go against DSS in KIRC, KIRP, GBMLGG, HNSC, PAAD. This evidence concerns the gene MTHFR and adrenal cortex carcinoma.