MTHFR and neoplasm: Taken together, analysis of genomic, transcriptomic and clinic features comprehensively demonstrates statistical correlations between MTHFR and prognostic significance, immune infiltration, heterogeneity and stemness indices across tumor types, and beneficially understands the functions of MTHFR as a potential biomarker in immune infiltration, TME, tumorigenesis and ICBs from the perspective of clinical tumor samples.