MTHFR demonstrates merely positive relations to dozens of IRGs, such as CX3CR1, CCR4, TAP2, HLA-E, TGFBR1, IL6R, TNFSF13, et al. However, heat map displays several cancer types such as CHOL and UCS show almost few relationships between MTHFR and the immune related genes. Here, HLA-E is linked to cancer.