CD8A and cancer: In XCELL algorithm of most cancers, MTHFR is positively correlated with the, CD4+T-cells, CD8+T cell, CD4 naive T cell, mast cell and osteoblast and others, negatively correlated with CD8 naive T cell, Th1 and Th2 cell, Mucoid Exopolysaccharide, et al. But the results are quite different when it comes to a specific tumor.