In MPTP‐treated PD mice, we noted decreased C9orf72 protein content in SNpc, dysregulated autophagy, and the accumulation of autophagic substrates (Figure 1A–E); moreover, the dopaminergic neuronal expression of tyrosine hydroxylase‐positive SNpc was decreased (Figure S1A,B). The gene discussed is TH; the disease is Parkinson disease.