In addition, the AJCC/UICC 8th Edition New Staging Rules recommended using p16 IHC only as a surrogate for HPV status and divided oropharyngeal carcinomas patients into p16+ patients and p16− ones, so in the actual process of diagnosis and treatment, doctors do not have to identify the HPV type. Here, CDKN2A is linked to oropharyngeal carcinoma.